Transformative Research in Metabolism
The NIH COBRE-funded center for (TRiM) at the University of Alaska is housed within the Institute of Arctic Biology and collaborates with UAA as a partner institution. The center supports interdisciplinary biomedical research to study hibernation and metabolism with the long-term goal of developing therapies to treat metabolic diseases such as diabetes, obesity, sarcopenia, and cardiovascular disease. TRiM’s supported research uses genomic, proteomic and metabolomic data to inform target identification, and in vitro and in vivo studies in non-hibernating species to confirm efficacy of target manipulation. This work is expected to enhance healthy aging and lessen the burden of metabolic disease and trauma.
Arctic ground squirrel near Toolik Field Station.